Allogeneic HSCT uses stem cells from a human leukocyte antigen (HLA) -matched donor, either related or unrelated, and, in malignant diseases, exploits a graft-versus-tumor effect. Autologous transplants involve harvesting the patient’s own stem cells and then returning them, typically after the patient has received doses of chemotherapy that are myeloablative. The role of HSCT in pediatric diseases depends in part on the indication for which it is being used. Hematopoietic stem-cell transplantation (HSCT) refers to a procedure in which hematopoietic stem cells are infused to restore bone marrow function in patients, and is categorized by the source of the stem cells. Remission means there is no sign of the cancer.Background and Objectives for the Systematic Review With lymphoma, leukaemia and myeloma the aim is to put the cancer into remission. Your doctor might explain that a transplant will try to cure your disease or control it for as long as possible. The aim of your transplant will depend on your situation. You might have a bone marrow transplant if collecting stem cells has been difficult in your situation. blood counts tend to recover quicker following a stem cell transplant.your team can usually collect more cells from the bloodstream.it’s easier to collect stem cells from the bloodstream than bone marrow.Bone marrow transplants are not used as much. Stem cell transplants are the most common type of transplant. A bone marrow transplant uses stem cells from your bone marrow, or a donor’s bone marrow. This is also called a peripheral blood stem cell transplant. A stem cell transplant uses stem cells from your bloodstream, or a donor’s bloodstream.
The main difference is whether stem cells are collected from the bloodstream or bone marrow. What is the difference between a stem cell and bone marrow transplant?
AUTOLOGOUS STEM CELL TRANSPLANT DEFINITION FULL
you are not fit or well enough for full intensity conditioning.Some healthy cells and cancer cells are left behind after treatment has finished. With RIC you have lower doses of treatment. You have very high doses of treatment and all the cancer cells and healthy cells are destroyed. Your doctor might also call this myeloablative conditioning or MAC. full intensity (myeloablative) conditioning.There are different strengths of conditioning treatment for a donor transplant. You usually have high dose conditioning treatment for a transplant using your own stem cells. The cells find their way to your bone marrow where they start making blood cells again. or a donor's stem cells (donor transplant)Īfter the treatment, you have the stem cells into your bloodstream through a drip.To prepare for your transplant, your team either collect: But it also kills the stem cells in your bone marrow. radiotherapy to your whole body (called total body irradiation or TBI)Ĭonditioning treatment aims to kill cancer cells.Conditioning treatment usually includes chemotherapy and you might also have: Platelets help to clot the blood to prevent bleeding.īefore your transplant, you have conditioning treatment.
White blood cells are part of your immune system and help to fight infection. Red blood cells contain haemoglobin which carries oxygen around the body. These stem cells develop into red blood cells, white blood cells and platelets. Stem cells are very early cells made in the bone marrow. Bone marrow is a spongy material that fills the bones. The stem cells are collected from the bloodstream or the bone marrow. It is also a treatment for other blood conditions.Ī transplant allows you to have high doses of chemotherapy and other treatments.
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